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24, chemin de Borde Rouge -Auzeville - CS52627 31326 Castanet Tolosan cedex - France

Last update: May 2021

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Aquapôle INRA

Inra Bordeaux-Aquitaine
Quartier Ibarron
64310 Saint-Pée-sur-Nivelle

tél : +33 (0) 5 59 51 59 51
fax : +33 (0) 5 59 54 51 52

Françoise Médale

DR 2

Françoise Médale
© inra, 2008
Fish Nutrition and energy metabolism - Interactions Genotypes x diets - Development of novel fish feed based on plant ingredients as substitutes for fish meal and fish oil

Contact | ActivitiesPartnerships | CoursesPublications


UMR NuAGe (Nutrition Aquaculture and Genomics)
Team : Nutrition,Métabolism andt Aquaculture
Pôle Hydrobiologie INRA
Quartier Ibarron
64310 St Pée-sur-Nivelle France
Tel : +33 (0)5 59 51 59 97
Fax: +33 (0)5 59 54 51 52
Email :

Management and expertise activities

Head of UMR 1067 NuAGe, joint Unit de INRA, Ifremer, Univ. Bordeaux I
Member of the INRA National Scientific Committee
Member of the Commission INRA Research Management
Member of the National Committee of the Universities - Section 68
Expert AFSSA group "Nutritional and healthy properties of aquatic products"

Research activity

1. Cursus and training

PhD Nutrition Sciences, University P. Sabatier Toulouse, 1985 -
Master in Animal Physiology and Biochemistry, University Toulouse III, 1981
Employed at INRA since 1985, Research director since 2000.

2. Major research activity

My research program aims at understanding the cellular and molecular mechanisms underlying nutrient utilization for energy purposes. I study the consequences of dietary supply on energy metabolism and body composition (energy stores) of farmed fish, using rainbow trout as the main model. The objectives are i) to reduce nitrogen utilization for energy production in order to limit nitrogen wastes and to enhance protein deposition ii) to manage body fat depots through nutritional strategies to improve fish flesh quality. In ongoing studies on fishmeal and fish oil replacements by alternative protein and lipid sources, I am also looking at the potential interactions between genotypes and diets. I use genomic tools to identify the metabolic pathways that are affected by the dietary changes.

Key-words: fish, nutrition, energy metabolism, muscle, fat deposition, nitrogen retention, plant protein sources, vegetable oils, enzymes activity, genomics, proteomics.

Running projects and main collaborations

  • Program "Nutritional and genetic determinism of fat depots in fish" – Collaborations: Scribe INRA Rennes, LGP Inra Jouy-en-Josas, STAM Ifremer Nantes.
  • European Project AquaMax : Sustainable aquafeeds to maximize the health benefits of farmed fish for consumers
  • Genetic variability of utilization efficiency of plant ingredients based diets – Collaborations: LGP Inra Jouy-en-Josas, AGP Ifremer Palavas, Nutrition des Poissons marins Ifremer Brest


  • University Rennes I/ Agrocampus – Master Biology and Agronomy: Physiological base of fish nutrition
  • ENITA Bordeaux – Engineers in Animal Production: Fish nutrition
  • ESAP Toulouse – Engineers in Animal Production: Nutrition of farmed fish and flesh quality
  • University "Pau et Pays de l'Adour" (UPPA) – Anglet – L2 Biochemistry : Regulation of energy metabolism

Publications selection

  • Gutières, S., Damon, M., Panserat, S., Kaushik, S., Médale, F., 2003. Cloning and tissue distribution of a Carnitine Palmitoyltransferase I gene in rainbow trout (Oncorhynchus mykiss). Comp. Biochem. Physiol. B, 135: 139-151.
  • Médale, F., Lefèvre, F., Corraze, G., 2003. Qualité nutritionnelle et diététique des poissons : constituants de la chair et facteurs de variations. Cah. Nutr. Diét. 38(1): 37-44.
  • Rollin, X., Médale, F., Gutières, S., Blanc, D., Kaushik, S.J., 2003. Short and long term nutritional modulation of Acetyl-Coenzyme A Carboxylase activity in selected tissues of Rainbow Trout (Oncorhynchus mykiss). British J. Nutr., 89(6) : 803-810.
  • Capilla, E., Médale, F., Panserat, S., Vachot, C., Rema, P., Gomes, E., Kaushik, S., Navarro, I., Gutierrez, J., 2004. Response of hexokinase enzymes and insulin system to dietary carbohydrates in common carp, Cyprinus carpio. Reprod. Nut. Dev., 44 (3): 233-242.
  • Quillet, E., Le Guillou S., Aubin J., Labbé L., Fauconneau B., Médale F., 2007. Response of a lean muscle and a fat muscle rainbow trout line (Oncorhynchus mykiss) on growth, nutrient utilization, body composition and carcass traits when fed two different diet. Aquaculture, 269 (1-4): 220-231.
  • Kolditz, C, Borthaire, M, Richard, N, Corraze, G, Panserat, S, Vachot, C, Lefèvre, F, Médale, F., 2008. Liver and muscle metabolic changes induced by dietary energy content and genetic selection in rainbow trout (Oncorhynchus mykiss). Am J Physiol Regul Integr Comp Physiol 294: R1154-R1164