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INRA
24, chemin de Borde Rouge –Auzeville – CS52627
31326 Castanet Tolosan CEDEX - France

Dernière mise à jour : Mai 2018

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NutriNeuro: Integrated Nutrition and Neurobiology Lab

Zone de texte éditable et éditée et rééditée

Psychoneuroimmunology and Nutrition: experimental and clinical approaches

Nutrition and Psychoneuroimmunology : experimental and clinical approaches

Lucile Capuron, DR1 INRAE lucile.capuron@inrae.fr

Sophie Layé, DR1 INRAE sophie.laye@inrae.fr

Depression research axis : Lucile Capuron

Our multidisciplinary team aims at understanding how nutrition may modulate brain functions and vulnerability to psychiatric disorders with a particular attention paid to major depression. We test the hypothesis that Western diet, diabetes or obesity through the modulation of inflammatory and metabolic pathways participate to the pathophysiology of depression and impact response to antidepressant treatments. We are currently exploring the specific role of: i) enzymatic pathways involved in inflammatory processes, such as the indoleamine2,3-dioxygenase (IDO) and the guanosine triphosphate cyclohydrolase 1 (GTP-CH1) ; ii) gut-brain axis dysfunctions and iii) early life stress in the pathophysiology of depression in a context of altered nutritional status. For this purpose, we adopt a translational research approach from humans to animal models and vice versa, combining the skills and expertise of researchers and clinicians.

Innovative techniques : clinical assessment; symptom dimensions; metabolic/ inflammatory phenotyping ; preclinical animal models ; psychopharmacology; neurochemistry; epigenetics; transcriptomics.

Researchers:

Bruno Aouizerate (Professeur Universitaire - Praticien hospitalier) 

Lucile Capuron (Directrice de recherche INRAE) 

Nathalie Castanon (Chargée de recherche INRAE) 

Muriel Darnaudery (Professeure) 

Didier Delhaye (Hospital head assistant)

Olivier Doumy (Praticien hospitalier)

Sylvie Vancassel (Chargée de recherche INRAE)

Technicians :

Sandra Dexpert (Ingénieure/technicienne INRAE) 

Julie Sauvant (Ingénieure/technicienne INRAE)

Post-docs :

Sofia Cussotto (Post-doctorante)

  

Doctorants :

Ines Delgado (Doctorante) 
Camille Monchaux (Doctorante)

Molecular and cellular mechanisms axis : Sophie Layé

Molecular and cellular mechanisms of nutrients/micronutrients in the brain; role in mood and cognitive disorders (Equipe FRM)

The research program develop aims to unravel the mechanisms underlying nutrients (sugar, fatty acids, amino-acids) and micronutrients (vitamins) activities in the brain, at the cellular (neurons, microglia) and brain circuit level. This knowledge will help to decipher how nutrition promotes brain health and protects from mood and cognitive disorders. We study in particular how 1) Omega 3 and their metabolites (oxylipins, endocannabinoids) regulate neuroinflammation and neuronal networks (focusing on the hippocampus and fronto-striatal circuits), 2) sugar (glucose, fructose) control of food intake (hypothalamus) and emotional behavior (raphe nucleus) 3) micronutrients or plant extracts protect from cognitive decline, with clinical approaches developed in aged subjects with V Pallet (team 2).

Integrative nutritional and neurobiological technical approaches: behavior (feeding behavior, emotion, motivation, cognition); In vitro and in vivo electrophysiology/optogenetic; lipidomic; Neuronal and glial cell culture; neuroimmunology; transcriptomics; nutrient sensing; genetic animal models; two-photon imaging; metabolism; dietary design; multiplex; FACS; 

Researchers:

Sophie Layé (Directrice de recherche INRAE) 

Jean-Christophe Delpech (Chargé de recherche INRAE)

Xavier Fioramonti (Chargé de recherche INRAE)

David Jarriault (Chargé de recherche INRAE)

Corinne Joffre (Chargée de recherche INRAE) 

Charlotte Madore-Delpech (Chargée de recherche FRM)

Pierre Trifilieff (Chargé de recherche INRAE)

Anne-Laure Dinel (Chef de projet NutriBrain) 

 

ITAs :

Agnès Aubert (Technicienne INRAE)

Véronique De Smedt-Peyrusse (Ingénieure INRAE) 

Alexandra Séré (Adjoint technique Université de Bordeaux)

Post-docs :

Mathieu Di Miceli (Equipe FRM PRINSS)

Moïra Rossito (Post-doctorante)

Roman Walle (Post-doctorant)  

Doctorants :

Mathilde Chataigner (CIFRE)

Fanny DeCoeur (IDEX, co-direction ME Tremblay, LIA OptiNutriBrain)

Hugo Martin (INRAE-Nouvelle Région Aquitaine)

Maud Martinat (INRAE, co-direction R Bazinet, RRI Food4BrainHealth)

Anna Petitbon

Selected publications :

Chrétien C, Fenech C, Liénard F, Grall S, Chevalier C, Chaudy S, Brenachot X, Berges R, Louche K, Stark R, Nédélec E, Laderrière A, Andrews ZB, Benani A, Flockerzi V, Gascuel J, Hartmann J, Moro C, Birnbaumer L, Leloup C, Pénicaud L, Fioramonti X. Transient Receptor Potential Canonical 3 (TRPC3) Channels Are Required for Hypothalamic Glucose Detection and Energy Homeostasis. Diabetes. 2017 Feb;66(2):314-324

Layé S, Nadjar A, Joffre C and Bazinet RP, Anti-inflammatory effects of omega-3 fatty acids in the brain: Physiological mechanisms and relevance to pharmacology, Pharmacological Reviews, 2018 Jan;70(1):12-38

Labrousse VF, Leyrolle Q, Amadieu C, Aubert A, Sere A, Coutureau E, Grégoire S, Bretillon L, Pallet V, Gressens P, Joffre C, Nadjar A* and Layé S*, Dietary omega-3 deficiency exacerbates inflammation and reveals spatial memory deficits in mice exposed to lipopolysaccharide during gestation, Brain Behavior and Immunity, 2018 Jun 4. pii: S0889-1591(18)30220-4.

Rey C, Delpech JC, Madore C, Nadjar A, Greenhalgh AD, Amadieu C, Aubert A, Pallet V, Vaysse C, Layé S, Joffre C. Dietary n-3 long chain PUFA supplementation promotes a pro-resolving oxylipin profile in the brain. Brain Behav Immun. 2019 Feb;76:17-27.

Bazinet RP, Layé S. Polyunsaturated fatty acids and their metabolites in brain function and disease. Nat Rev Neurosci. 2014 Dec;15(12):771-85.

Lafourcade M, Larrieu T, Mato S, Duffaud A, Sepers M, Matias I, De Smedt-Peyrusse V, Labrousse VF, Bretillon L, Matute C, Rodríguez-Puertas R, Layé S, Manzoni OJ. Nutritional omega-3 deficiency abolishes endocannabinoid-mediated neuronal functions. Nat Neurosci. 2011 Mar;14(3):345-50.

Ducrocq F, Hyde A, Fanet H, Oummadi A, Walle R, De Smedt-Peyrusse V, Layé S, Ferreira G, Trifilieff P, Vancassel S. Decrease in Operant Responding Under Obesogenic Diet Exposure is not Related to Deficits in Incentive or Hedonic Processes. Obesity (Silver Spring). 2019 Feb;27(2):255-263.

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