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NutriPsy: Nutrition and Neuropsychiatric symptom dimensions

NutriPsy

Leader: Lucile Capuron, DR1 INRAE lucile.capuron@inrae.fr

Deputy leader: Marie-Pierre Moisan, DR2 INRAE marie-pierre.moisan@inrae.fr

Team presentation

The overarching scientific objective of the Nutripsy team is to understand how nutrition can contribute to mental health, and to identify the mechanisms by which nutritional imbalances promote the development of neuropsychiatric symptoms, focusing on inflammatory processes. For this purpose, we propose a translational and integrative research program with the following complementary specific aims:

i) to elucidate the mechanisms by which inflammation, in relation to dietary habits, leads to neuropsychiatric symptom dimensions and antidepressant resistance

ii) to determine the influence of environmental factors and genetic variants related to inflammation on depressive symptoms and antidepressant response in clinical and preclinical models of nutritional imbalances,

iii) to propose innovative personalized treatment strategies through targeted nutritional approaches guided by the clinical, biological/inflammatory, and nutritional profiles of patients.

This research program represents a critical step toward a precision medicine applied to mental health, in a context where the efficacy of standard treatments remains mitigated.

Research axes

Axe 8: Nutrition and Mental Health

Axe 6: Psychiatric Pathologies

Researchers

Nathalie Castanon (Chargée de recherche INRAE)

Muriel Darnaudery (Professeure)

Sylvie Vancassel (Chargée de recherche INRAE)

Quentin Leyrolle (MCU UB)

Clinicians

Bruno Aouizerate (Professeur Universitaire - Praticien hospitalier)

Pascal Barat (Professeur Universitaire - Praticien hospitalier)

Julie Brossaud (Maître de conférences Universitaire - Praticien hospitalier)

Jean-Benoît Corcuff (Maître de conférences Universitaire - Praticien hospitalier)

Amandine Ferrière (MDPhD CHU)

Technicians - Engineers

Sandra Dexpert (IE INRAE)

Aline Foury (IE INRAE)

Jean-Christophe Helbling (IE INRAE)

Eva Bruchet (TR INRAE)

Post-docs

Camille Amadieu

Rachel Ginies

Enrica Montalban

Cassandra Gheorghe

Doctorants

Juliette Montet

Publications

A new experimental design to study inflammation-related versus non-inflammation-related depression in mice. Cardinal P, Monchaux de Oliveira C, Sauvant J, Foury A, Darnaudéry M, Vancassel S, Castanon N, Capuron L.J Neuroinflammation. 2021 Dec 11;18(1):290.

Influence of pro-obesogenic dietary habits on stress-induced cognitive alterations in healthy adult volunteers. Delgado I, Dexpert S, Sauvant J, Cryan JF, Capuron L.

Neurobiol Stress. 2021 Jun 12;15:100353. doi: 10.1016/j.ynstr.2021.100353. eCollection 2021 Nov.

Transcriptomic signaling pathways involved in a naturalistic model of inflammation-related depression and its remission.Moisan MP, Foury A, Dexpert S, Cole SW, Beau C, Forestier D, Ledaguenel P, Magne E, Capuron L.Transl Psychiatry. 2021 Apr 6;11(1):203.

Saffron Extract-Induced Improvement of Depressive-Like Behavior in Mice Is Associated with Modulation of Monoaminergic Neurotransmission. Monchaux De Oliveira C, Pourtau L, Vancassel S, Pouchieu C, Capuron L, Gaudout D, Castanon N.Nutrients. 2021 Mar 11;13(3):904.

Relationship between body mass index and neuropsychiatric symptoms: Evidence and inflammatory correlates. Huet L, Delgado I, Dexpert S, Sauvant J, Aouizerate B, Beau C, Forestier D, Ledaguenel P, Magne E, Capuron L. Brain Behav Immun. 2021 May;94:104-110.

Special Issue: The intersection of inflammation and metabolism in neuropsychiatric disorders. Felger JC, Capuron L.Brain Behav Immun. 2021 Mar;93:331-334.

Multi-hit early life adversity affects gut microbiota, brain and behavior in a sex-dependent manner. Rincel M, Aubert P, Chevalier J, Grohard PA, Basso L, Monchaux de Oliveira C, Helbling JC, Lévy É, Chevalier G, Leboyer M, Eberl G, Layé S, Capuron L, Vergnolle N, Neunlist M, Boudin H, Lepage P, Darnaudéry M.Brain Behav Immun. 2019 Aug;80:179-192

Brain tumor necrosis factor-α mediates anxiety-like behavior in a mouse model of severe obesity. Fourrier C, Bosch-Bouju C, Boursereau R, Sauvant J, Aubert A, Capuron L, Ferreira G, Layé S, Castanon N.Brain Behav Immun. 2019 Mar;77:25-36.

Inflammatory bases of neuropsychiatric symptom domains: mechanisms and specificity. Aouizerate, B., Vancassel, S., Castanon, N., Capuron, L., 2021 In: Immuno-Psychiatry. Facts and prospects. M. Berk, M. Leboyer, I. E. Sommer (eds), Springer, chapter 20, pp 335-353.

Tetrahydrobioterin (BH4) Pathway: From Metabolism to Neuropsychiatry.

Fanet H, Capuron L, Castanon N, Calon F, Vancassel S.Curr Neuropharmacol. 2021;19(5):591-609. Review.

Modification date : 01 March 2024 | Publication date : 08 December 2010 | Redactor : CJ